anti-inflammatory and antimicrobial studies of biosensitive knoevenagel condensate β-ketoanilide schiff base and its co(ii), ni(ii), cu(ii) and zn(ii) complexes

a new series of transition metal complexes of co(ii), ni(ii), cu(ii) and zn(ii), has beensynthesized from the knoevenagel condensate schiff base ligand(l) derived from β-ketoanilideand furfural with o-phenylenediamine and diethylmalonate. structural features were determinedby spectral and analytical techniques. square-planar geometry has been adopted by thecomplexes except cobalt complex which has an octahedral geometry. the synthesized ligand andits complexes were screened for their anti-inflammatory activity in male albino rats(carrageenan-induced rat paw oedema model). among these complexes, copper complex showssignificant anti-inflammatory activity. it exhibits significant dose dependent activity in acuteinflammation. the doses of 100 and 200 mg kg-1 bw produced 38.3 % and 42.8 % inhibitionrespectively after 3 h as compared with that of the standard drug (indomethacin) which showed48.5 % inhibition. the in vitro antimicrobial activity of the ligand and its complexes wasmonitored by disc diffusion method. it has been found that complexes have higher antimicrobialactivity than that of free ligand.